Because the rejuvenation of aged tissues is observed in vitro, the generic elongation of telomeres in living animals might likely have a rejuvenating affect on tissues and organs in vivo, potentially resulting in significant rejuvenation of living humans including possibly substantial lifespan extension.

Human telomerase and its catalytic subcomponent telomerase reverse transcriptase are very large molecules that cannot be sensibly delivered by traditional vectors such as viral based carriers and or liposome technologies. Telomolecular nanotechnologies offer effective delivery options for the practical and safe deliver large-molecules the size of TERT (or a variant thereof). ELMD1 has been studied in a variety of living animals and has delivered enzymes that were previously considered too large and complex to deliver across the membrane envelope to the nucleus of a cell. The results of these studies have been the advent of cutting-edge medical therapies for such problems as stroke and cancer. A variant of TERT or DNA nanocircles delivered with ELMD1 can lengthen chromosomal telomeres in living animals. This advance is likely to safely correct many age-related diseases and is expected to cause organismal rejuvenation. The opportunity to treat age-related diseases, which are presently without cures or therapies, is worth billions of dollars. Lengthening telomeres in lab cells is a process that is being used to grow organs and skin grafts by companies like Geron and has been tested in skin, livers, and other tissues and organs in some ways.