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Telomolecular is a regenerative medicine company focused on developing core intellectual property for which it has exclusive licenses from some of the USA's top research institutions. The Company's lead product candidates include nanoparticle delivery of compounds to treat the effects of ischemic stroke, reperfusion injuries and cardiovascular restenosis. In addition, the Company is developing a number of pioneering technologies to treat diseases of aging, chronic illness, cellular reconstruction and cancer.

Regenerative medicine is a rapidly expanding field. It consists of pioneering medical technologies that enable organisms to repair, replace, and regenerate aged, diseased, or damaged tissues, organs, and cellular structures. The market estimates for the regenerative medicine sector are approximately $5B for 2008 and are expected to grow to $11B by 2010 and $300B by 2020.

In early studies conducted at The Cleveland Clinic in 2008 the Company's lead product candidate was shown to reduce the necrotic effects of stroke ischemia in 75% of the subjects studied. The Company expects to move into further clinical studies and is optimistic that it may begin early human trials in 2009.

"More than 700,000 Americans will experience a new or recurrent stroke this year and 160,000 of them will die." 'Stroke leave many Americans unable to work or carry out their previous activities,' said Dr. Goldstein. "Because stroke leaves so many disabled it is also a threat to our economy-it is estimated to cost our nation $53.6 billion this year."

-The American Heart Association 2004

Telomolecular's second product candidate, the nanoparticle delivery of the p53 protein, is targeted at post angioplasty restenosis. Early stage testing has shown this product is effective in inhibiting restenosis with a corresponding increase in the lumen diameter. The Company plans to engage in further clinical study with the intention of moving into human trials in late 2009.

Telomolecular released its first commercial product in December of 2007. bĭm·ə·nē is a novel cosmeceutical product targeting the aesthetic medical market. bĭm·ə·nē utilizes the Company's nanotechnology capability to load recombinant human collagen type III and Hyaluronic acid into nanoparticles and deliver them topically as an aesthetic cream for anti-aging purposes.

Telomolecular's objective is to become a dominant company in these emerging markets. Our mission is to develop and commercialize regenerative medical technologies in large markets with unmet needs. Our strategy is to continue to aggregate a portfolio of compelling intellectual property. The financial strategy is to create one or more international entities, capitalize the structure with institutional and early stage investors, and achieve liquidity with a continuous roll out of commercialization projects based upon current and planned acquisitions of technologies consistent with our mission.

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About Our Technologies
Synthetic DNA nanocircles

Synthetic DNA nanocircles are a self-assembling nanotechnology shown to repair damaged telomeres in vitro. Nanocircles have been used successfully to rejuvenate cells and tissues and promise to be a therapeutically cost efficient solution to creating pharmaceutical products. As a more flexible, efficient, and inexpensive drug platform the future of telomere regeneration lies in nanocircle administration.
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Telomere Elongating Enzymes

The administration of telomere elongating enzymes has been used to repair damaged telomeres in new ways. The telomerase enzyme was first discovered by Dr. Harley and colleagues in 1999. Its use in cell cultures demonstrated that aged cells could be rejuvenated and caused to live thousands of times beyond their normal replicative limits. Telomolecular is the first group to prove that telomere elongating enzymes (which were once thought to be too large and sensitive to deliver in a gene therapy) can be successfully delivered to the cells of living organisms in a large molecule drug.
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Apoptosis Reactivation

Cancer and aging are interrelated subjects. By reactivating mutated or inactivated apoptosis function in cancerous tissues new nanotechnologies appear effecacious and non-toxic in the treatment of some types of human cancer. In the near future believe this technique can be optimized to become even more effective and safe. We feel there is no other single strategy that is better.
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Muscle Regeneration

Notch 1 is a technology that regenerates musculature, heart tissue, and neuronal tissue. A hallmark of aging is diminished regenerative potential of human musculature. The mechanism of this decline is now known. Analysis of injured muscle revealed that, with age, resident precursor cells (satellite cells) had a markedly impaired propensity to proliferate and to produce myoblasts necessary for muscle regeneration.
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Repair of Mitochondrial DNA

Mitofusin 1 can be used in the repair of damaged mitochondrial DNA. Mitochondria produce cellular energy that begins to run low with age. In the future it may become important to correct dysfunctional and aberrant mitochondrial DNA to solve certain diseases and restore cellular energy levels...
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Large Molecule Medicine

Large molecule medicine is the key to addressing problems of human aging and a wealth of human diseases that have been unresponsive to traditional medicine. Small molecules have limited size and specificity with which to interact with genes and pathogens in human cells. Very often small molecules are toxic to the human host and it is therefore difficult to develop safe small molecule drugs...
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Products & Therapies


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