"Telomolecular nanotechnologies may provide new and effective strategies in the treatment of human aging and age-associated disease."

	Telomeres: cap the ends of chromosomal DNA and consist of repeated sequences of the thymine, adenine, and guanine. They are longest at conception and become shorter each time a cell divides. This shortening eventually becomes critical and leads to cellular senescence and cell death as important sequences of DNA become exposed or fuse end-to-end. Cell function such as protein production, repair, and signaling, decline as telomeres shortens. In general, aging cells become progressively less able to form and maintain healthy tissue. This dysfunction plays a key role in a variety of presently incurable age-associated diseases such as macular degeneration, arteriosclerosis, atherosclerosis, osteoporosis, skin atrophy, Progeria and others. It can also be seen in symptoms we often label as human aging, such as wrinkled and deteriorating skin and the decline of vital organs. Some of the company’s core technologies include:
	Synthetic DNA Nanocircles: are a synthetic nanotechnology that have been shown to elongate chromosomal telomeres in vitro. They consist of DNA bases arranged in a circular sequence that templates the lengthening of telomeres by repeated addition of new TTAGGG sequences. Nanocircles have been used successfully to rejuvenate cells in vitro and hold promise as an efficient way of elongating telomeres in vivo.
	PLGA Biodegradable Nanoparticles: deliver molecules considered too large and complex to transport with known vectors. ELMD1 is non-toxic, does not illicit an immune response, causes comprehensive transfection, crosses the blood-brain barrier, and supports sustained drug release. Nanoparticles loaded with vTert or nanocircles can be used to treat age-associated diseases and possibly more general problems of aging.
	Nanoparticlecircles: By combining nanocircles and or oTrt with Telomolecular’s rights in the field of large-molecule delivery, Telomolecular believes it will be possible to develop breakthrough pharmaceutical products, and is working presently on the regeneration of human tissues in vivo.
	oTrt is a synthetic enzyme that elongates and repairs human telomeres. It is biologically too large to transport across human cell membranes with existing vectors, but might be distributed effectively throughout organisms with Telomolecular’s large molecule delivery system. This technique works in skin grafts.
	Notch 1: has been shown to regenerate musculature, heart tissue, and neuronal tissue called. A hallmark of aging is diminished regenerative potential of human musculature. The mechanism of this decline is now known. Analysis of injured muscle revealed that, with age, resident precursor cells (satellite cells) had a markedly impaired propensity to proliferate and to produce myoblasts necessary for muscle regeneration. Sufficient up-regulation of a special receptor ligand results in muscle, neuronal, and heart tissue regeneration in old musculature.
	Mitofusin 1: can be used in the repair of damaged mitochondrial DNA. Mitochondrial diseases result from failures of the mitochondria, specialized compartments present in every cell of the body except red blood cells. Mitochondria are responsible for creating more than 90% of the energy needed by the body to sustain life and support growth. When they fail, less and less energy is generated within the cell. Cell injury and even cell death follow. If this process is repeated throughout the body, whole systems begin to fail, and the life of the person in whom this is happening is severely compromised.
	p53 & pRB Reactivators: are inducible genes and enzymes (and the acquisition of licenses) that reactivate p53 DNA damage checkpoint control, pRB tumor suppressor, and other tumor suppressors. Inactivation of the p53 tumor suppressor protein, by mutation or by viruses, has been identified in over one-half of all human tumors. Delivery of the p53 gene to tumor cells has led to the elimination of tumors in both animal models and some early clinical studies. The retinoblastoma protein (pRb)/cyclin/cyclin-dependent kinase (Cdk)/p16 tumor-suppressor pathway participates in the regulation of cellular proliferation and undergoes mutational or epigenetic inactivation in essentially 100% of selected human malignancies. Reactivating this pathway appears to be a promising approach in delimiting human cancers.
	DNA, RNA, and siRNA production: permits DNA, RNA, and siRNA base pharmaceutical products to be produced in higher volumes in novel systems. The production of DNA, RNA and siRNA is a rapidly growing $40 billion industry however, current methods for producing DNA do not scale up well and are expensive. Telomolecular is working on technologies for producing DNA, RNA, and siRNA in transgenic plants, bacteria, and animals that is likely to reduce the cost of goods very significantly and permanently change the way pharmaceutical grade DNA is produced.